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“五一”假期出行火热 假期首日热门线路火车票开售“秒光”_我的网站

A |     央视网消息：2024年“五一”小长假共5天，探亲流、旅游流、学生流“三流叠加”，铁路客流将呈现强劲增长态势。4月17日开始，“五一”假期首日也就是5月1日的火车票正式发售，多条热门线路的车票“秒光”，出现大面积候补。　　假期首日热门线路火车票开售“秒光”　　记者在购票平台搜索发现，“五一”假期首日火车票开售后，多条热门线路的车票“秒光”。

B | 截至4月17日上午10时，北京至西安、成都、重庆、哈尔滨、郑州等多条线路部分车次的火车票已经售罄。　　春假假期车票销售火爆 抢票难度堪比“春运”　　4月28日—30日是浙江杭州中小学生春假，再衔接“五一”假期，8天的假期让不少家长将旅游出行提上日程。4月28日，杭州前往北京、长沙、广州等热门目的地的二等火车票处于基本售罄状态，不少家长表示抢票难度堪比“春运”。　　旅客可通过候补购票 多选增加成功率　　铁路部门提示，没有买到心仪车票的旅客，可以抓紧通过候补购票，多选几个日期、车次、席别组合提交候补订单，增加候补成功率。

C |     

    Qingyangshen, or Root of Auricledleaf Swallowwort, a traditional ethnic medicinal plant long used in Southwest China's Yunnan Province. Photo: Scrrenshot from website
A Chinese research team has identified a new potential target to develop antidepressant drug from Qingyangshen, or Root of Auricledleaf Swallowwort, a traditional ethnic medicinal plant long used in Southwest China's Yunnan Province, according to Kunming University of Science and Technology, Science and Technology Daily reported Sunday.
The team, led by professors Xu Tianrui and Xiang Cheng from the university's School of Life Science and Technology, found that Qingyangshen glycosides, the plant's core active compound, can alleviate depression-related behaviors by simultaneously suppressing inflammation, reducing oxidative damage and stabilizing neurotransmitters in the brain.
The findings were published in the international journal Phytomedicine.  
Depression has become a widespread mental health disorder globally, while existing clinical drugs fail to provide effective treatment for more than 30 percent of patients, according to the researchers. Previous studies have established a strong link between chronic inflammation and depression, but existing anti-inflammatory drugs have limited targeting capabilities, underscoring the need for new therapeutic targets and lead compounds.
Qingyangshen, a plant of the Cynanchum genus in the Apocynaceae family, has long been used as a traditional medicine by ethnic groups including the Naxi, Yi and Bai peoples in Yunnan, mainly for treating neurological conditions such as epilepsy and neurasthenia. 
The researchers systematically examined the pharmacological effects of Qingyangshen extract and its core active compound, Qingyangshen glycosides. Tests using mouse, zebrafish and fruit fly models repeatedly showed that the compound significantly improved depression-related behaviors induced by inflammation, according to the report.
To identify the compound's target, the team developed a dual-discrimination model for four subtypes of prostaglandin E2 receptors and combined it with AI-powered machine learning. The researchers screened hundreds of G protein-coupled receptors and identified the prostaglandin E2 subtype 4 receptor as the direct target of Qingyangshen glycosides.
Multiple molecular experiments confirmed that the compound binds directly to the receptor and acts as an inhibitory ligand. Further experiments involving animals with the receptor knocked out in the hippocampus showed that the antidepressant effects of Qingyangshen glycosides disappeared completely when the receptor was absent, providing the first in-vivo evidence that the receptor is essential for the compound's therapeutic effects.
    An illustration of the research. Photo: Screenshot from the website
The study establishes the prostaglandin E2 subtype 4 receptor as a potential new target for antidepressant drug development and points to a new approach to treating depression through inflammatory pathways. It also identifies Qingyangshen glycosides as a potential lead compound for developing highly targeted anti-inflammatory antidepressants, creating a research chain from ethnic medicinal plants and active compounds to drug targets and new drug development.
Global Times
。铁路部门也会根据售票情况增加运力。　　　“五一”假期出行火热 机票预订进入高峰　　除了火车票，“五一”假期的机票预订也进入高峰。航旅纵横大数据显示，截至目前，“五一”假期期间，国内航线机票预订量超过220万，比一周前增长近62%；出入境航线机票预订量超过69万，比一周前增长约17%。上海、北京、成都、广州、深圳、杭州、西安、重庆、昆明、武汉是“五一”假期十大国内热门目的地，出境游也成为旅客的热门选择。

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